Our IVM Results
In the past, our pregnancy rates with IVM are included as part of conventional IVF cycles in the SART data reporting for IVF programs. However, mixing this data makes it impossible to understand how well a program is doing with IVM. (It also makes the reported results for IVF less relevant since if many patients or doing IVM, it changes the population available to do IVF.) We no longer participate in SART data reporting. Our results are reported on our web site broken down by the type of IVF cycle undertaken.
Delivered pregnancy rate per transfer is the most useful in understanding the quality of a program, However, many of the published clinical summaries of programs with IVM emphasize clinical pregnancy rates per transfer (which is higher) rather than delivered or ongoing pregnancy rates per transfer.
The best results generally report (clinical) pregnancy rates in the 25-35% range. Miscarriages are likely to be increased in IVM cycles compared to conventional IVF cycles. We believe this is because miscarriages are also increased in patients with PCO (with high antral follicle counts). The best study on this issue is out of McGill University and suggests that the miscarriage rate after IVM is similar to the miscarriage rate after IVF or ICSI when PCO is taken into account.
Since pregnancy always carries the risk of miscarriage, we believe that the best way to understand pregnancy results is to think in terms of the ongoing or delivered pregnancy rate per transfer. We provide several types of information (including cycle cancellations) to help readers better understand the true results.
Clinical pregnancy rate per transfer was- 12/26 or 46.2%
Ongoing or delivered pregnancy rate per transfer- 3/26 or 11.5%
Patients with no embryos to transfer after an egg aspiration- 0/26 or 0%
2012 Results for IVM cycles*
Clinical pregnancy rate per transfer was- 7/17 or 41.2%
Ongoing or delivered pregnancy rate per transfer- 4/17 or 23.5%
Patients with no embryos to transfer after an egg aspiration- 1/18 or 5.6%
Clinical pregnancy rate per transfer was- 8/16 or 50%
Delivered pregnancy rate per transfer- 7/16 or 43.8%
Patients with no embryos to transfer after an egg aspiration- 0/16 or 0%
2010 Results for IVM cycles*
Clinical pregnancy rate per transfer was 12/33 or 36.4%
Delivered pregnancy rate per transfer- 7/33 or 21.3%
Patients with no embryos to transfer after an egg aspiration- 5/38 or 13.2%
(2010 to present)
Clinical pregnancy rate per transfer was 39/92 or 42.4%
Ongoing or delivered pregnancy rate per transfer- 21/92 or 22.8%
Patients with no embryos to transfer after an egg aspiration- 6/98 or 6.1%
*These are patients undergoing IVM who have not had a prior (failed) conventional IVF cycle. This also excludes those patients undergoing rescue IVM. Primary IVM patients were both younger and had higher antral follicle counts than our routine IVF patients. Patients underwent 1, 2, or 3 cycles.
Another way of looking at how successful IVM is in terms of how many patients leave with a baby after being recommended for IVM and undertaking it. This is because IVM (and Mini-stim IVF) are much easier and less costly than conventional IVF. Clearly, the cost per pregnancy is much lower in our selected IVM patients than in age comparable conventional IVF patients. The cycle cancellation rate is also similar to conventional IVF and if current trends continue may be also superior to conventional IVF.
If patients fail to get pregnant in a cycle, they either undergo another IVM cycle, move on to conventional IVF, utilize Mini-IVF or drop out of the program. The decision to continue with IVM or move to IVF is usually a joint doctor/patient decision made based on details of the cycle or cycles undertaken.